Laryngopharyngeal dysthesia (LPD) in oxaliplatin infusion (OXLP).

In the present study, we have encountered about 100% sensitivity to Ciprofloxacin by disc diffusion method but Nalidixic acid resistance was about 89%. Interestingly, 80 out of 93 isolates of Salmonella typhi (86.02%) and 37 out of 38 isolates of Salmonella paratyphi A (97.36%) were Nalidixic acid resistant; MIC for Ciprofloxacin being more than 1 μg/ml. This implies that Nalidixic acid resistance is associated with higher MIC’s for Ciprofloxacin rendering Fluoroquinolones clinically ineffective in-spite of sensitivity shown by disc diffusion method in-vitro. But most of the microbiology laboratories resort to disc diffusion method for sensitivity testing, making it imperative for a clinician to look for Nalidixic acid sensitivity before prescribing Fluoroquinolones to the patient with salmonellosis.